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| tcsgroupx | Дата: Среда, 04.03.2015, 11:14:36 | Сообщение # 76 |
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Группа: Гости
| Docetaxel (as generic or underneath the shoppers specify Taxotere) is a clinically well-established anti-mitotic chemotherapy medication (medication which interferes with apartment compartmentation). It is acclimated to mostly to the treatment of mamma, ovarian, prostate, and non-small cell lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved claim after treatment of patients who have locally advanced, or metastatic titty or non small-cell lung cancer who partake of undergone anthracycline-based chemotherapy and failed to hold back cancer progression or relapsed[4 - and a European approval for work in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the journal Drugs, docetaxel administered as a one-hour infusion every three weeks approximately over a ten return track, docetaxel is considered as or more basic than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - Respect the effectiveness of docetaxel versus paclitaxel and other taxanes is undisturbed controversial. A variety of more late-model articles father found "no sign that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge list old to be and is at rest considered efficient but fashionable studies are indicating a weekly outline authority be better. A 2010 article in Prevailing Clinical Pharmacology states, "weekly government has emerged as the optimal schedule." Docetaxel is marketed worldwide under the high regard Taxotere during Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.[citation
Nature
Docetaxel is of the chemotherapy opiate savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an extract from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Owed to dearth of paclitaxel, international research was carried peripheral exhausted primary to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and readily ready European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl working dispose on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain instead of the benzyl amide in paclitaxel. The carbon 10 going team mutation causes docetaxel to be more sea water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a pale-complexioned authority and is the working ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The mixing is a discerning brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing chestnut single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a singular dose Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose for administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and financially sound vials are combined to give a settling of 10 mg/mL and the required dispense is tense from this solution. Vials be suffering with an overfill to balance for liquid impoverishment during preparation, foaming, adhesion to vial walls and the dead volume. 20 mg vials may be stored for 24 months under 25 °C away from insight and 80 mg vials since 26 months in the yet conditions.[8 -
Recently Sanofi has got okay payment one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion emulsion is simplified nearby eliminating the before dilution step. The two-vial and one-vial formulations carry the unchanged dose substance, docetaxel trihydrate, and the same excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous result that contains the done drug theme in the selfsame concentration as the already approved two-vial formulation. The same grade, status, and sum of polysorbate 80 are closest in the infusion revelation of both formulations. The however unlikeness between these two formulations is the sum of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| Cliyernm | Дата: Вторник, 24.03.2015, 2:45:03 | Сообщение # 78 |
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Группа: Гости
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| Belluccidar | Дата: Среда, 15.04.2015, 5:56:53 | Сообщение # 79 |
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Группа: Гости
| индивидуалки Казани
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| managerKt | Дата: Воскресенье, 19.04.2015, 7:35:11 | Сообщение # 80 |
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Группа: Гости
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